Phytochemical-based vesicular system for the treatment of vitiligo: A review

Vitiligo is a depigmenting disorder that causes white patches on the skin and mucosa. It has an impact on a patient’s mental well-being, physical wellbeing, and human lifestyle. These depigmented macules were originally mentioned in preHindu, Vedic, and ancient Egyptian manuscripts more than 3,000 years ago. In recent years, there has been a growing interest in using phytochemicals over synthetic compounds in the pharmaceutical field. To better understand the effectiveness of natural products in the fight against vitiligo, large-scale clinical trials are required. Here, in this study, we summarize a list of vesicular formulations, with and without phytochemicals, that have been used and will be utilized in the future to treat vitiligo. To assist further progress in this vitiligo review we hereby mention an overview of pathophysiology, recent updates on clinical trials, and patents.