Evaluation of Serum 25-hydroxyvitamin D Levels in Children with The First Episode of Seizures

Background Seizures have been prevalent among children leading to critical complications and death in some cases, investigation of the reasons for seizures is of great importance. We aimed to assess the influence of 25-hydroxyvitamin D deficiency in children with the first episode of on seizures. Materials and Methods: This study was a case control study and carried out on 1 to 16-year-old children of Besat Hospital of Sanandaj, Kurdistan province, Iran, with the first episode of seizures (case), and children who were referred for routine laboratory checkup (control) in the year 2020. Serum 25-hydroxyvitamin D level was measured by chemiluminescence immunoassay methods of blood sample for both case and control groups. The required data were collected and entered in SPSS software version 21.0 to be analyzed. Results: Total individuals of 120 children [72 (60%) boys] with an average age of 46.77+40.5 months were selected. Sixty-two patients (51.7%) of the children received an appropriate vitamin D supplement, and prevalence of vitamin D supplementation use was higher in case group (P=0.011).The average serum level of 25-hydroxyvitamin D in individuals was 31.36+19.01 and the average serum level of vitamin D in the patient group was greater than that of the control group (P=0.003).The frequency of 25-hydroxyvitamin D deficiency was higher in the control group (P=0.001). Conclusion Based on the obtained results, an important conclusion can be reached that seizures in children were not effectively prevent by normal vitamin D supplements.