Author/Authors :
Taheri, Diana Department of Pathology - Isfahan Kidney Diseases Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Roohani, Elham Department of Pathology - Isfahan Kidney Diseases Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Izadpanahi, Mohammad Hossein Department of Urology - Isfahan Urology and Kidney Transplantation Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Dolatkhah, Shahaboddin Department of Internal Medicine - Iran University of Medical Sciences, Tehran, Iran , Aghaaliakbari, Farshad Department of Internal Medicine - Iran University of Medical Sciences, Tehran, Iran , Daneshpajouhnejad, Parnaz Department of Pathology - Isfahan Kidney Diseases Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Gharaati, Mohammad Reza Department of Urology - Isfahan Urology and Kidney Transplantation Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Mazdak, Hamid Department of Urology - Isfahan Urology and Kidney Transplantation Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Fesharakizadeh, Shahriar Department of Biochemistry - San Francisco State University, San Francisco, USA , Beinabadi, Yasasmin Department of Pathology - Noble Pathology Laboratory, Isfahan, Iran , Kazemi, Reza Department of Urology - Isfahan Urology and Kidney Transplantation Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Rahbar, Mahtab Department of Pathology - Iran University of Medical Sciences, Tehran, Iran
Abstract :
Background: Considering the great variations in the reported prevalence of prostate cancer across the world possibly due to different
genetic and environmental backgrounds, we aimed to determine the expression pattern and the diagnostic utility of α‑methylacyl
coenzyme A racemase (AMACR) among Iranian patients with prostate adenocarcinoma. Materials and Methods: In this cross‑sectional
study, formalin‑fixed paraffin‑embedded tissues of 58 patients with a definitive pathologic diagnosis of prostatic adenocarcinoma
were evaluated. The expression of AMACR, intensity, and extensity of its staining was determined in selected samples by
immunohistochemical technique. Results: AMACR expression was significantly higher in neoplastic compared to normal
tissue (P < 0.05). The expression of AMACR was significantly associated with the age of the patients (P = 0.04). The intensity of the
staining was associated with the grade of the prostate adenocarcinoma (P = 0.04). There was no significant relationship between
AMACR expression and perineural invasion. The sensitivity, specificity, positive predictive value, and negative predictive value of
AMACR were 90%, 96%, 96%, and 90%, respectively. Conclusion: Findings from our study indicate that AMACR could be used as
a diagnostic tool for the diagnosis of prostate adenocarcinoma. However, due to false‑positive staining in the mimicker of prostatic
adenocarcinoma, it is recommended to use it in combination with basal cell markers.
