The Relationship between Platelet Volume Indices (PVIs) and Epileptic Seizure

Background: Platelet volume indices (PVIs) are low on price and easily accessible criteria in today’s medicine. However, the impact of PVIs on seizure characteristics in epileptic patients is not clear. Aim: To assess the level of PVIs in seizure affected patients and to see if there is a relationship between these results and the clinical status of patients. Methods: The current study enrolled patients with the epileptic seizure (ES) to evaluate the PVIs for investigating whether a relationship exists between PVIs levels with duration, frequency and type of seizure. In this survey, the platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and platelet count (PLT) were calculated for the patient. Results: A total of 199 patients were included in the study period, for which 59 attacks were focal seizures and 149 attacks were generalized convulsive seizures. The platelet counts and PCT were significantly higher in focal seizure than in generalized convulsion seizure. In generalized onset, MPV was significantly higher as compared to the focal onset. Conclusion: The acquired data indicated that the high level of MPV and low level of PLT and PCT in generalized seizures might substantially contribute to the clinical signs of epileptic patients.