Title of article :
The frequency, related cause of disease, and treatment of hepatitis B virus infection: A systematic review and meta‑analysis in Iran
Author/Authors :
Kalvandi, Gholamreza Associate Professor of Pediatrics Gastroenterology Department of Pediatrics, School of Medicine Besat Hospital - Hamadan University of Medical Sciences, Hamadan, Iran , Abangah, , Ghobad Associate Professor of Gastroenterology and Hepatology - School of Medicine - Shahid Mostafa Khomaeini Hospital - Ilam University of Medical Sciences, Ilam, Iran, , Veisani, Yousef Research Assistant Professor of Epidemiology Department of Epidemiology - School of Health Psychosocial Injuries Research Center Ilam University of Medical Sciences, Ilam, Iran , Nourmohammadi, Hassan Assistant Professor of Hematology and Oncology - Department of Internal Medicine - School of Medicine - Shahid Mostafa Khomaeini Hospital - Ilam University of Medical Sciences, Ilam, Iran , Golitaleb, Mohamad Instructor of Critical Care Nursing Department of Nursing - School of Nursing Arak University of Medical Sciences, Arak, Iran , Tavan, Hamed Clinical Research Development Unit - Shahid Mostafa Khomeini Hospital - Ilam University of Medical Sciences, Ilam, Iran
Abstract :
Background: Hepatitis B virus (HBV) is one of the most dreadful viruses causing high mortality rates and serious damages to hepatocytes. The aim of this study was to assess the frequency, related causes/risk factors, and treatments of HBV infection in Iran by systematic review and meta‑analysis. Materials and Methods: The data were obtained by a literature search in the PubMed, Scopus, SID, and Web of Sciences databases. Keywords included prevalence, risk factors, causes, treatment, and HBV. The Persian equivalents of these keywords were also searched. The time span included 2004 to2021. The Q and I
2 statistics were used to check heterogeneity among studies. The data were analyzed using Stata (version 14). Results: The frequencies of HBV infection and its pharmaceutical
therapy were P = 6% (95% confidence interval [CI]: 4–9, I2 = 95.2%, P < 0.001) and 19% (95% CI: 18%–30%, I2 = 98.9%, P < 0.001), respectively. The most common risk factors/causes of HBV were narcotic consumption, blood‑related factors, and transmission from infected individuals with the respective frequencies of 27% (95% CI: 16%–38%, I2
= 88.7%, P < 0.001), 32% (95% CI: 11%–53%, I2 = 99.8%, P < 0.001), 25% (95% CI: 10%–41%, I
2 = 99.3%, P < 0.001), and 15% (95% CI: 7%–22%, I2 = 98.4%, P < 0.001), respectively.
Conclusion: The most important causes of HBV infection were transmission from infected people, narcotic consumption, and blood‑related factors. The main therapeutic intervention for HBV was pharmaceutical therapy
Keywords :
Hepatitis B virus , meta‑analysis , treatment , frequency
Journal title :
Journal of Research in Medical Sciences
