Peculiarities of Clinical and Morphological Characteristics of Patients on the Local-advanced Malignant Tumors of the Thyroid Gland

Aims: The main purpose of the study is to study and compare clinical and morphological characteristics, as well as the results of comprehensive treatment of patients with locally advanced malignant thyroid tumors T4a and T4b stage, compared with tumors without T1-3 invasions, to determine the main factors influencing the prognosis disease. Material & Methods: All patients were given standard methods of research: sonographic study of thyroid glands and organs and lymphatic nodes of the neck, palpation of the neck, thin-needle aspiration puncture biopsy of thyroid gland, tumor and lymphatic nodes of the neck. Hormonal studies (thyrotropin hormone, free thyroxine, thyroglobulin and antibody to it, calcitonin), general and biochemical analyzes of blood with electrolytes, separate ionized calcium for the elimination of parathyroid gland carcinoma, coagulogram, electrocardiogram, radiologic studies organs of the thoracic cavity. Findings: It was found that the study group of invasive tumors T4, depending on the degree of spread of invasion, more reliable men, a more elderly average age of patients, a higher percentage of regional and remote metastasis, a higher percentage of low morphological differences of tumors as well as a higher percentage of radioiodine-refractory well differentiated cancers. Conclusion: All of the above listed factors worsen the expected response to treatment of patients, which indicates the necessity of "aggressive", most radical surgical interventions in the complex treatment of these patients.