Author/Authors :
Topal, Dursun Department of Cardiology - Bursa Education and Research Hospital - Health Sciences University, Bursa, Turkey , Onur Mutluer, Ferit Department of Cardiology - Faculty of Medicine - Koc University, Istanbul, Turkey , Aydin, Omur Department of Cardiology - Kilis State Hospital, Kilis, Turkey , Cakir, Hakan Department of Cardiology - Bursa Education and Research Hospital - Health Sciences University, Bursa, Turkey , Kanat, Selcuk Department of Cardiology - Bursa Education and Research Hospital - Health Sciences University, Bursa, Turkey , Aslan, Burhan Department of Cardiology - Gazi Yaşargil Education and Research Hospital, Diyarbakir, Turkey , Er, Fahri Department of Cardiology - Agri State Hospital, Agri, Turkey , Uslu, Abdulkadir Department of Cardiology - Kosuyolu Education and Research Hospital, Istanbul, Turkey , Ozlem Bozkaya, Veciha Department of Cardiology - Zekai Tahir Burak Education and Research Hospital, Ankara, Turkey , Keskin, Muhammed Department of Cardiology - Istanbul Sultan Abdulhamid Han Education and Research Hospital, Istanbul, Turkey , Karşı, Remzi Department of Midwifery - School of Health Sciences - The Konya Chamber of Commerce Karatay University, Konya, Turkey , Yılmaz, Mustafa Department of Cardiology - Faculty of Medicine -Uludağ University, Bursa, Turkey , Aksakal, Enbiya Department of Cardiology - Faculty of Medicine - Medicana Hospital - Biruni University, Bursa, Turkey , Demir, Mehmet Department of Cardiology - Bursa Education and Research Hospital - Health Sciences University, Bursa, Turkey , Tenekecioglu, Erhan Department of Cardiology - Bursa Education and Research Hospital - Health Sciences University, Bursa, Turkey
Abstract :
Background: We aimed to investigate the relationship between hemoglobin A1c (HbA1c) and coronary thrombus load in type‑2
diabetes mellitus (T2DM) patients with non‑ST segment elevation myocardial infarction (NSTEMI). Materials and Methods:
Ninety diabetic patients with NSTEMI were recruited for the study. They were separated into two groups according to HbA1c levels.
Forty‑seven patients having HbA1c ≤6.5% formed Group‑I (35 male, mean age 58 ± 10.5 years) and the remaining 43 patients with
HbA1c >6.5% formed Group‑II (23 male, mean age 58 ± 11.1 years). Both the groups were evaluated in terms of thrombolysis in
myocardial infarction (TIMI) thrombus score and Syntax score. Results: Baseline patient characteristics were comparable in both
the groups. TIMI thrombus score and Syntax score were higher in Group II than in Group I (3.2 ± 1.4 vs. 4.7 ± 0.5 and 20.2 ± 3.4 vs.
26.3 ± 3.0 respectively, P < 0.05). No significant difference was found in other parameters. In stepwise linear regression analysis,
prepercutaneous coronary intervention (PCI) and post‑PCI TIMI frame number and HbA1c were significantly related to the coronary
thrombus scale. However, no significant relationship has been found between thrombus formation and hypertension, previous PCI
history, pre‑PCI heart rate, pre‑PCI cholesterol status, and high‑sensitive troponin T. Conclusion: In NSTEMI with T2DM, increased
HbA1c (HbA1c >6.5%) is related with coronary thrombus in the target vessel. In those patient population, strict anticoagulation
should be considered to prevent potential adverse events.
