Indirect Sensitive Determination of Oxymetazoline. HCl in Pure Pharmaceutical Drugs and Biological Samples Using a Modified Sensor Unit Via a Green Method of FI/MZ System

A new FI method was examined with many advantages such as simplicity, high sensitivity and accuracy, economical in terms of material consumption, environmentally friendly, and less hazardous to laboratory with the minimum volume of reactants. Flow injection analysis is a process employ for estimation of Oxymetazoline hydrochloride in pharmaceutical forms by spectrophotometric with merging zone technology. This method depends on the oxidation-reduction reaction a cross the oxidizing agent the drug while reducing it to iron(II). The reduced form reacts with the reagent 2,2`-bipyridyl to give a pink complex is measured at λmax (521) nm. Linear calibration curve obeyed Beer s law 10-500 μg.mL^-1 with detection limit 6.195 μg.mL^-1 for the developed FIA method. The velocity of sampling was 72 sample.h^-1, the RSD was 2.716%, and the average recovery was 101%. By using distilled water as a carrier of chemicals with this analytical technique, it is less dangerous and less polluted. The suggested method was effectively used to estimate OXY in medicinal drugs and biological materials. The obtained results were statistically treated and comparable to the official method (British Pharmacopeia).