Title of article
Curcumin as an effective suppressor of miRNA expression in patients with knee osteoarthritis
Author/Authors
Atabaki, Mahdi Clinical Immunology Research Center - Zahedan University of Medical Sciences, Zahedan, Iran , Shariati-Sarabi, Zhaleh Rheumatic Diseases Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Tavakkol-Afshari, Jalil Immunology Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Taghipour, Ali Department of Epidemiology - Social Determinants of Health Research Center - School of Health - Mashhad University of Medical Sciences, Mashhad, Iran , Jafari, Mahmood Reza Nanotechnology Research Center - Pharmaceutical Technology Institute - Mashhad University of Medical Sciences, Mashhad, Iran , Nikpoor, Amin Reza Molecular Medicine Research Center - Hormozgan Health Institute - Hormozgan University of Medical Sciences, Bandar Abbas, Iran , Mohammadi, Mojgan Immunology Research Center - Mashhad University of Medical Sciences, Mashhad, Iran
Pages
11
From page
346
To page
356
Abstract
Objective: Osteoarthritis is the most common disease in the group of joint diseases, and its incidence is directly related to aging. Given the anti-inflammatory effects of curcumin as an active ingredient of turmeric, we aimed to investigate the effects of this compound in a new curcumin nanomicelle formula named SinaCurcumin® on the expression of microRNAs (miRNAs) involved in immune responses of patients with osteoarthritis.
Materials and Methods: We divided 30 patients with osteoarthritis into two groups namely, nano curcumin-receiving (15 patients) and placebo-receiving (15 patients) and we studied them for 3 months. The Iranian Registry of Clinical Trials (IRCT) approved our study with the IRCT registry No. IRCT20151028024760N4. We evaluated the rates of the expression of microRNAs 146, 155, 16, and 138 employing SYBR Green Real-Time PCR method.
Results: The expression of miRNAs 155, 138, and 16 revealed a significant reduction in the curcumin-receiving group (p=0.002, p=0.024 and p=0.0001 respectively).
Conclusion: Our research data indicated that the consumption of curcumin in patients with osteoarthritis could affect the immune system partially via altering the expression of microRNAs and cytokines.
Keywords
Curcumin , MiR-146 , MiR-15 , MiR-138 , MiR-16 , Osteoarthritis
Journal title
Avicenna Journal of Phytomedicine (AJP)
Serial Year
2022
Record number
2729803
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