Author/Authors :
Pillegowda Smitha, Kolavanahalli Department of Pharmaceutics - Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India , Srinivas Kulashekar, Kuruba Department of Pharmacology - Sri K.V. College of Pharmacy - Chickballapur, Karnataka, India , Krishnappa Pavithra, Thotlaganahalli Department of Pharmaceutics - Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India , Ashok Kumar, Bagepalli Srinivas Department of Pharmacognosy - Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India , Saran, Gopi Setty Department of Pharmaceutics - Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India
Abstract :
Sitopaladi Churna is an ayurvedic formula, traditionally used as anti-inflammatory, carminative,
sedative, expectorant, anti-infective, and various respiratory disorders. The aim of the present
study is to screening for alpha amylase (α-amylase) inhibition activity of aqueous extract of
Sitopaladi Churna. In vitro α-amylase inhibition activity of Sitopaladi Churna was screened by the
3,5-dinitrosalicylic acid method. Sitopaladi Churna showed potent (α-amylase) inhibitory activity
with an IC50 - 46.38 μg/ml. Thus, Sitopaladi Churna may consider as a remedy for diabetes and
other insulin resistance-related diseases; however, animal and human studies are needed to
confirm this activity.
Keywords :
Dinitrosalicylic Acid , Alpha Amylase , Diabetes , Ayurvedic Formula , Sitopaladi Churna
