Title of article :
Histological Changes and Ghrelin, P-Selectin, and Leptin Parameter in Patients with Hepatic Hydatidosis in Iraq
Author/Authors :
Hassan Abood, A Faculty of Sciences - University of Kufa - Kufa, Iraq , Khteer Al-Hadraawy, S Faculty of Sciences - University of Kufa - Kufa, Iraq , Abdulhur Alibraheemi, N College of Medical Sciences - University of Kufa - Kufa, Iraq , Zabibah, R. S Department of Radiology Techniques - College of Medical Technology - The Islamic University - Najaf, Iraq , Khalfa, H. M Faculty of Sciences - University of Kufa - Kufa, Iraq
Abstract :
Humans and animals are affected by hydatid cyst disease as a worldwide zoonotic disease, which is caused by
the metacestode stage of Echinococcus spp. This study was performed to evaluate the histological change of
liver and blood concentrations of biomarkers, such as ghrelin, p-selectin, and leptin, in humans infected with
hydatid cyst. A total of 30 surgical specimens of liver and blood of infected humans and 30 healthy individuals
as a control group were evaluated. Liver tissue sections in cases infected with hydatid cyst and control group,
histological abnormalities in the liver, including fibrosis, increased inflammatory cells, dystrophic areas, and
necrosis were compared in this study. In addition, serum leptin levels were significantly lower in patients with
hydatid cyst disease than in the control group (P-value<0.05), whereas p-selectin and ghrelin levels significantly
decreased in patients (P-value<0.05). The results of this research can be effective in improving and promoting
the treatment programs of hydatidosis.
Keywords :
P-selectin , Kufa , Leptin , Hydatid disease , Histological change , Ghrelin
Journal title :
Archives of Razi Institute
