Author/Authors :
Hajiesmaeil, Mogge Department of Biology and Biotechnology "Charles Darwin" - Sapienza University of Rome - Rome, Italy. , Mirzaei Dahka, Samaneh Student Research Committee - Guilan university of Medical Sciences - Rasht, Iran , Khorrami, Ruin Garmsar Islamic Azad university - Garmsar, Iran , Rastgoo, Samira Departments of Clinical Nutrition and Dietetics - Faculty of Nutrition and Food Technology - National Nutrition and Food Technology Research Institute - Shahid Beheshti University of Medical Sciences - Tehran, Iran. , Bourbour, Fatemeh Departments of Clinical Nutrition and Dietetics - Faculty of Nutrition and Food Technology - National Nutrition and Food Technology Research Institute - Shahid Beheshti University of Medical Sciences - Tehran, Iran. , Davoodi, Hossein Faculty of Nutrition and Food Technology - Departments of Clinical Nutrition and Dietetics - National Nutrition and Food Technology Research Institute - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Shafiee, Fatemeh Nutrition Research Center - School of Nutrition and Food Sciences - Shiraz University of Medical Sciences - Shiraz, Iran. , Gholamalizadeh, Maryam Student Research Committee - Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran. , Torki, Saheb Abbas Department of Nutrition - Faculty of Nutrition Sciences - Shiraz University of Medical Sciences - Shiraz, Iran. , Akbari, Mohammad Esmail Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Doaei, Saeid Reproductive Health Research Center - Department of Obstetrics and Gynecology - Al-Zahra Hospital, School of Medicine - Guilan University of Medical Sciences - Rasht, Iran
Abstract :
Background: The risk of cervical cancer was reported to be influenced by dietary components. This study aimed to illustrate the association between cervical cancer with the intake of food groups in women with a history of cervical neoplasia.
Methods: This nested case-control study was conducted in 558 people with a history of cervical intraepithelial neoplasia (CIN), including 279 women with cervical cancers and 279 controls with low-grade squamous intraepithelial lesions (LSIL). A validated food frequency questionnaire (FFQ) was used to assess the intake of food groups.
Results: The intake of fruits and vegetables in the case group was significantly lower than the control group (P=0.001). Low intake of dairy products, vegetables, and fruits was associated with cervical cancer risk (OR=4.67; 95% CI 1.2-9.49, P=0.001; OR=9.75, 95% CI 1.36-19. 51, P=0.001; and OR=4.82, 95% CI 1.09-7.25, P=0.001, respectively). After adjusting for age, family history, age at first menstruation, number of children, history of vaginal infection, and age at first sexual intercourse, the results were still significant. Additional adjustments to BMI did not change the results.
Conclusion: The results indicate that the risk of cervical cancer can be affected by the intake of certain food groups. Further longitudinal studies are needed to confirm these findings and determine the underlying mechanism of the influence of dietary components on cervical cancer risk.
Keywords :
Cervical cancer , Cervical intraepithelial neoplasia , Dietary intake , Food group
