Author/Authors :
Seyed Alinaghi, Ahmad Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Karimi, Amirali School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Pashaei, Zahra Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Afzalian, Arian School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Mirzapour, Pegah Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Ghorbanzadeh, Kobra Department of Nursing - Khalkhal University of Medical Sciences, Khalkhal, Iran , Ghasemzadeh, Afsaneh Department of Radiology - Tabriz University of Medical Sciences, Tabriz, Iran , Dashti, Mohsen Department of Radiology - Tabriz University of Medical Sciences, Tabriz, Iran , Nazarian, Newsha School of Medicine - Islamic Azad University, Tehran, Iran , Vahedi, Farzin Department of Nursing - Khalkhal University of Medical Sciences, Khalkhal, Iran , Tantuoyir, Marcarious M. School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Shamsabadi, Ahmadreza Department of Health Information Technology - Esfarayen Faculty of Medical Sciences, Esfarayen, Iran , Dadras, Omid Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Mehraeen, Esmaeil Department of Health Information Technology - Khalkhal University of Medical Sciences, Khalkhal, Iran
Abstract :
Introduction: Knowledge of vaccine-related adverse events is crucial as they are among the most important factors
that cause hesitation in receiving vaccines. Therefore, we aimed to systematically review the adverse events
related to the mRNA vaccines reported in the literature. Methods: A systematic literature search was carried out
in the databases of Scopus, PubMed, Cochrane, and Web of Science. We selected original studies that explored
the side effects of mRNA COVID-19 vaccines using a two-phase (title/abstract and full-text) screening process.
Results: Cardiac complications were the most commonly reported severe adverse events. It appeared that systemic
adverse reactions are more common after the second dose of vaccines. The number of adverse effects
reported after the Pfizer vaccine was higher than other vaccines, mostly due to its earlier approval and more
widespread use throughout the world. Cardiac adverse events had a higher prevalence but no significant association
has been found between COVID-19 mRNA vaccines and cardiac adverse events except for myopericarditis.
Conclusion: Vaccines play a crucial role in controlling the COVID-19 pandemic and decreasing mortalities and
the results of the present review acknowledge the fact that the benefits outweigh the adverse events of these
vaccines
