Title of article :
The Effect of Methanolic and Ethanolic Extracts of Ruta graveolens L. Leaves on Formalin-Induced Inflammation in Rats
Author/Authors :
Mirghazanfari, Sayid Mahdi Students' Scientific Research Center - Tehran University of Medical Sciences, Tehran, Iran , Abbassian, Alireza Department of Traditional Medicine - School of Medicine - AJAUniversity of Medical Sciences; Tehran, Iran , Kamalinejad, Mohammad Department of Pharmacognosy - School of Pharmacy - Shahid Beheshti University, Tehran, Iran , Karimian, Morteza Department of Physiology - School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Massoud, Ahmad Department of Immunology - School of Medicine - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
The phenomenon of inflammation is the base of many acute and chronic diseases. New effective antiinflammatory
drugs are needed to battle side effects of acute and especially chronic inflammation and
incomplete treatment of patients suffering from these side effects. For this purpose, in the present
study, we evaluated Ruta graveolens L. (R. graveolens) as a folk herb for treatment of inflammation.
In an experimental-interventional study, anti - inflammatory effects of R. graveolens, a Persian
Medicine (PM) plant, were examined with formalin-induced hind paw edema model in rats. Sodium
Salicylate (300mg/kg, ip, SS) was injected as a positive control group and compared with three doses
of methanolic extract of R. graveolens (Meth) (50, 100 and 200 mg/kg; i.p.), two doses of ethanolic
extract of R. graveolens (Eth) (50 and 100 mg/kg; i.p.) and a group of distilled water (6 mL/kg; i.p.).
The results showed that R. graveolens has acute and chronic anti-inflammatory properties and
prevents inflammation. These effects were found to be effective like SS.
Keywords :
Ethanolic extract , Ruta graveolens L , Inflammation , Formalin test , Traditional Iranian Medicine , Methanolic extract
Journal title :
Traditional and Integrative Medicine
