Synthesis and Characterization of Bis-Flavone Imine Derivatives

For different pharmacological activities to treat various diseases, many naturally occurring and synthesized flavonoid derivatives are explored. Certain molecules have drawn the particular interest because of their possible health advantages, such as the antioxidant capabilities of these polyphenolic compounds. By removing free radicals from the environment or chelating metal ions, the functional hydroxyl groups in flavonoids mediate their antioxidant activities. All of the following features are present: antiviral, antiinflammatory, hepatoprotective, antioxidant, antithrombotic, vasodilating, and anticarcinogenic, along with a high effectiveness and low toxicity. By refluxing one mole of bis-Schiff base chalcone with two moles of DMSO/I2, new bis-flavone imine has been synthesized. Synthesized bis-flavone structures were determined by 1H-NMR, 13C-NMR, and Mass spectrum as well as the anticancer activity (MCF-7) of bis-flavone imine.