Preparation of Fe3O4-Au @ Fe3O4-Ag Composite Nanoparticles and Cytotoxicity Study of kidney parameters in mice

Magnetic Fe3O4 nanoparticles covered with gold and silver particles were prepared by hydrothermal method, and for the successful coating of gold and silver particles on Fe3O4 surface, the nanoparticles showed good dispersion and solubility in the physiological phase. Characterization was carried out on the nanoparticles that were obtained using X-ray diffraction, transmission electron microscopy, and vibration sample magnetometry (VSM). (Fe3O4-Au @ Fe3O4-Ag) nanoparticles are between 8 and 22 nm and 4 to 16 nm in size, respectively, exhibiting supermagnetism and highly saturated magnetization at room temperature. Also, available data on in vivo toxicity are limited. The advantage of the current study is to evaluate the toxicity of (Fe3O4-Au @ Fe3O4-Ag) nanoparticles by morphological and functional criteria. The biochemical parameters of the organism were also evaluated using an animal model. MNPs were injected intraperitoneally for (7, 14, 21 and 28) days. In addition, histological examination was studied in kidney samples. Our results also show that there are no significant changes in biochemical parameters. Where the tissue was kept without any change during the entire period when monitoring. As well as no significant body weight occurred during the testing period and after MNPs particle injection.