Synthesis, Characterization, and Computational, Biological Studies of Four-membered Cyclic Amides 2- azetinones

Two compounds,3-benzoyl-2-(4-bromophenyl)-3-phenyl-6 – oxa-2-azaspiro[3.4]octan-1-one and 1 ,1 -bis(3-bromo-4-(dimethylamino)phenyl)-4,4 ,5,5 -tetrahydro-2H,2 H-tetraspiro[furan-3,2 -azetidine-4 ,1 -acenaphthylene-2 ,2 -azetidine-3 ,3 -furan]-3 ,4 -dione, were synthesized by tetrahydro furan-3-carboxylic acid and appropriate imines. Two studies were conducted on the prepared compounds, one of them is the study of their anti-biological efficacy using two types of bacteria Staphylococcus aureus and Escherichia coli, The other study that was conducted on the compounds is a computational study to calculate some of the thermodynamic parameters of synthesized derivatives by using a Gaussian program.