Preparation and Identification of New 1,4-bis (5,3-substituted-2,3-dihydro-1H-pyrazole-1-yl) Buta-1,4-Dione Derivatives with Their Antibacterial Effect Evaluation

A new series of 5,3-substituted-2,3-dihydro-1H-pyrazole derivatives (P1-10) have been synthesized via a cyclization reaction of substituted chalcones with succinichydrazide. Structures of the prepared compounds were identified by FT-IR, and some of them were characterized by Nuclear Magnetic Resonance for proton 1H-NMR and Nuclear Magnetic Resonance for carbon 13C-NMR. The heat of formation (HF) and steric energy (SE) have been calculated using (MOPAC) and (MM2) methods, respectively, using (CS-Chemoffice-version 6.0) program. Additionally, the biological activity for final products has been evaluated against gram-positive (staphylococcus aureus and staphylococcus epidermidis) and negative bacteria (escherichia coli and pseudomonas aeruginosa).