Ultra violet estimation of promethazine HCl in pharmaceutical formulation and industrial waste water sample

A new method is proposed to detect and precisely determining of promethazine HCl. This procedure is easy, straightforward, quick, and cost-effective technique. It is applicable to a wide range of samples, environmental, municipal wastewater, and of course, pharmaceutical preparations (for both tablets and injections). The highest absorbance value was obtained at 248 nm of a uniform content in distilled water. This procedure obeys Beer-Lambert low at a range of 0.5-15 µg/mL, while the registered molar absorptivity is 2.8X104 L.mol-1.cm-1, whereas the relative standard deviation is less than 2%, and the accuracy (average recovery%) is 100 ± 0.9. This technique was substantiated by sensitivity and precision which confirms appropriation for regular analysis of promethazine HCl in actual samples.