Moderate-intensity continuous training and probiotic consumption on IL-15 gene expression in an animal model of non-alcoholic steatosis

Steatosis is the most important cause for chronic liver disease, from simple steatosis to advanced stages such as liver fibrosis and cirrhosis and liver cancer. In this study, the effect of Moderate Intensity Continuous Training (MICT) and probiotic consumption was examined on IL15 gene expression in an animal model of non-alcoholic steatosis. This study adopted an experimental laboratory design. Thirty-two male Wistar rats were divided into 4 groups of 8: the healthy (normal diet), steatosis, steatosis + probiotic, steatosis + probiotic +MICT groups and were tested for 8 weeks. The exercise protocol was as follows: in the first week from 10 minutes of running at a speed of 18 meters per minute to the eighth week with 60 minutes of running at a speed of 28 meters per minute. Considering the consumption of probiotics, the relevant groups received 109 CFU / ml of Lactobacillus rhamnosus GG by gavage daily for 5 weeks and 5 days a week. Statistical calculation of this study was performed using SPSS 25 software. The results showed that probiotic consumption and moderate-intensity continuous training significantly increased IL-15 (p =0.000) while they significantly decreased TG (p =0.000) in the non-alcoholic steatosis animal model. It seems moderate-intensity continuous training with probiotic consumption can improve the liver function of non-alcoholic fatty liver patients.