Title of article :
Role of Non-coding RNA as a Biomarker of Response to Therapeutic Agents in Colorectal Cancer
Author/Authors :
Mahmoudi ، Roghayeh Research Center for Molecular Medicine - Hamadan University of Medical Sciences , Salem ، Elham Research Center for Molecular Medicine - Hamadan University of Medical Sciences , Khadempar ، Saedeh Departemant of Medical Genetics - Shahid Sadoughi University of Medical Sciences , Rastgoo Haghi ، Alireza Department of Pathology - Hamadan University of Medical Sciences , Keshtpour Amlashi ، Zahra Departemant of Radiotherapy - Hamadan University of Medical Sciences , Saki ، Sahar Hamadan University of Medical Sciences , Darvishi Talemi ، Masoumeh Department of Biology - Faculty of Science - Bu-Ali Sina University , Afshar ، Saeid Research Center for Molecular Medicine - Hamadan University of Medical Sciences
Abstract :
Chemoresistance is a severe drawback to the successful and effective treatment of colorectal cancer (CRC). Comprehensive molecular mechanisms of chemoresistance facilitate the development of effective therapeutic strategies to overcome chemoresistance in CRC. The dysregulation of several non-coding RNAs was related to chemoresistance in CRC.Considering the importance of lncRNAs and miRNAs as prognostic and response to treatment biomarkers, this review focuses on the role of miRNAs and lncRNAs in CRC chemoresistance. Non-coding RNAs have an essential role in tumor progression, metastasis, and CRC chemoresistance. Thus, miRNAs and lncRNAs can be used to respond to therapeutic biomarkers in CRC.
Keywords :
Colorectal Neoplasm , Chemoresistance , lncRNA , miRNA
Journal title :
Jentashapir Journal of Cellular and Molecular Biology
Journal title :
Jentashapir Journal of Cellular and Molecular Biology
