Title of article :
Diagnostic Accuracy of Alpha-Methylacyl-CoA Racemase Immunohistochemical Expression for the Diagnosis of Ovarian and Endometrial Clear Cell Carcinomas
Author/Authors :
Nili ، Fatemeh Department of Pathology - Cancer Institute, Imam Khomeini Hospital Complex - Tehran University of Medical Sciences , Fathi ، Soheib Department of Pathology - Cancer Institute, Imam Khomeini Hospital Complex - Tehran University of Medical Sciences , Tavakoli ، Mansoureh Department of Pathology - Cancer Institute, Imam Khomeini Hospital Complex - Tehran University of Medical Sciences , Mirzaian ، Elham Department of Pathology - Shariati Hospital - Tehran University of Medical Sciences , Lotfi ، Maryam Department of Pathology - Amir-Alam Hospital - Tehran University of Medical Sciences
From page :
57
To page :
63
Abstract :
Background Objective: Clear cell carcinoma (CCC) is an uncommon histopathologic subtype of ovarian and endometrial carcinoma. Due to the morphologic overlapping with other subtypes of ovarian and endometrial carcinomas, an accurate diagnosis is crucial. Methods: In this study, 31 cases of ovarian clear cell carcinoma (OCCC), 28 endometrial clear cell carcinoma (ECCC), and 80 non-CCC subtypes (33 high-grade serous carcinomas of the ovary, 2 low-grade serous carcinomas, 10 ovarian endometrioid, 3 serous carcinomas and 29 endometrioid carcinomas of the endometrium) were investigated for immunohistochemical expression of AMACR. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for the distinction of OCCC and ECCC from other histopathologic subtypes were calculated. Results: Positive AMACR staining was seen in 18 OCCCs (58%) and 10 ECCCs (35.7%). In the non-clear cell group, 44 cases of ovarian (98%) and 25 cases of endometrial carcinoma (78%) showed negative results. Only one case of ovarian endometrioid carcinoma and 7 cases (22%) of endometrial endometrioid carcinomas revealed a positive reaction (P 0.05). Collectively, sensitivity, specificity, PPV, and NPV of AMACR expression, for the diagnosis of OCCC were calculated as 58%, 98%, 94.7%, and 77.2%, respectively. The sensitivity, specificity, PPV, and NPV were shown to be as 35.7%, 78.1%, 58.8%, and 58.1%, respectively in the endometrium. Conclusion: AMACR may be a highly specific immunohistochemical marker for the distinction of serous and clear cell carcinoma. A small percentage of endometrioid carcinoma may show positive staining. The sensitivity of this marker may not be higher than the other well-known Napsin-A IHC marker.
Keywords :
Accuracy , AMACR , Clear cell carcinoma , ovary , Endometrium , Immunohistochemistry
Journal title :
Iranian Journal of Pathology (IJP)
Journal title :
Iranian Journal of Pathology (IJP)
Record number :
2738595
Link To Document :
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