Title of article :
Frequency of HER2 Expression, MMR Deficiency, and PI3KCA Mutation in Pretreated Surgical Specimens of Patients with Esophageal Squamous Cell Carcinoma in Iran Cancer Institut
Author/Authors :
Salarvand Farzaneh Bagheri ، Samaneh Department of Clinical and Anatomical Pathology - Cancer Institute - Tehran University of Medical Sciences , Bagheri ، Farzaneh Department of Radiation Oncology - Cancer Institute - Tehran University of Medical Sciences , Gholizadeh ، Mahsa Radiation Oncology Research Center, Cancer Research Institute - Tehran University of Medical Sciences , Sharifi ، Sima Department of Clinical and Anatomical Pathology - Cancer Institute - Tehran University of Medical Sciences , Panahi ، Pooneh Department of Clinical and Anatomical Pathology - Cancer Institute - Tehran University of Medical Sciences , Esmati ، Ebrahim Department of Radiation Oncology - Cancer Institute - Tehran University of Medical Sciences , Lashkari ، Marzieh Department of Radiation Oncology - Cancer Institute - Tehran University of Medical Sciences , Jalaeefar ، Amirmohsen Department of Oncosurgery - Cancer Institute - Tehran University of Medical Sciences , Shirkhoda ، Mohammad Department of Oncosurgery - Cancer Institute - Tehran University of Medical Sciences , Shahsiah ، Reza Department of Clinical and Anatomical Pathology - Cancer Institute - Tehran University of Medical Sciences , Ghalehtaki ، Reza Department of Radiation Oncology - Cancer Institute - Tehran University of Medical Sciences
Abstract :
Background Objective: Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for the molecular pathogenesis of esophageal squamous cell cancer (ESCC), the role and frequency of HER2 expression, MMR deficiency, and PI3KCA mutation are not well defined. Methods: We carried out HER2/neu expression, dMMR/MSI high, and PI3KCA mutation analysis in specimens of patients with ESCC. We accessed archival tissue blocks related to specimens of 68 ESCC cases at the time of surgery following neoadjuvant chemoradiation. These patients underwent surgery during 2013-2018 at the Cancer Institute of Iran affiliated with the Tehran University of Medical Sciences in Tehran. Results: None of the patients showed HER2 expression, dMMR/MSI high, or PI3K mutations. Conclusion: dMMR/MSI-H and PI3KCA mutation and HER2 expression may not be reliable andfrequent targets for systemic therapy in patients with esophageal SCC.
Keywords :
DNA Mismatch Repair , Esophageal Neoplasms , HER Family Receptor , Kinase , Squamous Cell Carcinoma
Journal title :
Iranian Journal of Pathology (IJP)
Journal title :
Iranian Journal of Pathology (IJP)
