Synthesis of Novel Michael Adducts and Study of their Antioxidant and Antimicrobial Activities

In the current study, the Michael addition reaction of nitromethane to chalcones was considered. 4-benzeloxy benzaldehyde was synthesized from 4-hydroxybenzaldehyde and benzyl bromide, which was then converted to chalcone derivatives by reaction with substituted acetophenones, and finally nitromethane was added to give Michael adducts. The structures of the synthesized compounds were characterized by FT-IR, 1H NMR, and 13C NMR spectroscopy. All the products were screened for antioxidant, antimicrobial against Staphylococcus aureus G (+ve) and Escherichia coli G (-ve) microorganisms and antifungal activities against Candida albicans.