Title of article :
Tracheal Anatomy and Factors Contributing to Tissue Engineering
Author/Authors :
Nahumi ، Aida Department of Biology - Islamic Azad University, Shahrekord Branch , Panahi ، Yassin Department of Pharmacology and Toxicology - School of Pharmacy - Ardabil University of Medical Sciences (ArUMS) , Asadi ، Asadollah Department of Biology - Faculty of Science - University of Mohaghegh Ardabili , Abdolmaleki ، Arash Department of Bioinformatics - Faculty of Advanced Technologies - University ofMohaghegh Ardabili
Abstract :
The trachea is a respiratory organ, which connects the larynx to the main flageolet and the lungs, made up of cartilaginous rings and a mucosal layer-lined tube characterized by smooth muscle and connective tissue. Tissue engineering is one of the most promising and potent therapeutic approaches for curing long-segment tracheal stenosis. This study reviewed articles indexed in scientific databases including ISI, SID, PubMed, and PubMed Central between 1993 and 2022. Although three-dimensional scaffolds are a new therapeutic approach, they have opened up new avenues for renovating pathologically problematic tissues. This review article discusses the anatomy of the trachea and therapeutic approaches such as tissue engineering to construct tracheal cartilage to replace the damaged trachea. Next, we concisely review the recent advances in stem cell biology in scaffolds and their interplay with growth factors to optimize an engineered tracheal epithelium.
Keywords :
Trachea Engineering , Mesenchymal Stem Cells (MSCs) , Scaffolds , Growth Factor
Journal title :
Gene Cell Tissue
Journal title :
Gene Cell Tissue
