Smart On-Demand and Programmed Injectable Gels for Cancer Treatment

Hydrogels are often exploited biological materials in the transfer of biomolecules such as medications, DNA, and proteins owing to apparent features, including cytocompatibility and likeness to genuine human tissues. A number of biomaterials have the capacity to be injected, which allows for minimum invasion and eliminates the necessity of surgery to transplant pre-formed materials. This material is injected through the target location in a solution condition before gelling. If a stimulus generates gelation by the interaction of one or more stimuli, it can do so spontaneously. When such occurs, the material/system is referred to be stimuli-responsive since it reacts to its environment. In this context, we discussed the many triggers leading to gelation and reviewed the various processes by which the solution becomes a gel. We also reviewed several trials that used these gels to treat cancer. These materials show promise for treating cancer. Injectable hydrogels and stimuli-sensitive materials were the topics of several studies and reviews. To our knowledge, there has not been any research done on the use of smart injectable hydrogels for tumor therapy.