Title of article :
Assessment of Essential and Non-essential Elements as Risk Evaluation Indices in Men with Prostate Cancer in Calabar South-South Nigeria
Author/Authors :
Nsonwu-Anyanwu ، Augusta Department of Medical Laboratory Science, Calabar - University of Calabar , Icha ، Bassey Department of Chemical Pathology, Calabar - University of Calabar Teaching Hospital , Nsonwu ، Magnus Department of Optometry - Imo State University , William ، Mbetobong Department of Medical Laboratory Science, Calabar - University of Calabar , Emughupogh ، Krukru Department of Medical Laboratory Science, Calabar - University of Calabar , Usoro ، Chinyere Department of Medical Laboratory Science, Calabar - University of Calabar
From page :
285
To page :
292
Abstract :
Background: Heavy metal (HM) toxicity has been described as a risk factor for the development of prostate disease in men and its assessment could predict susceptibility to prostate cancer (PCa). The current study aimed to assess the levels of HM (selenium [Se], copper [Cu], chromium [Cr] and lead [Pb], iron [Fe], zinc [Zn], magnesium [Mg], and cobalt [Co]) in men with PCa.Method: 90 men aged 40 to 75 years, including 30 men with PCa, 30 with benign prostatic hyperplasia (BPH), and 30 controls, were recruited in this case-control study. Prostate specific antigen (PSA) was estimated via enzyme linked immunosorbent assay and heavy metals with atomic absorption spectrophotometry. Body mass index (BMI) was also determined.Results: The men with PCa had significantly higher BMI, PSA, Fe, and Pb and lower Mg, Zn, Cu, and Se compared with the controls. They also had higher PSA, Fe, and Co compared with the BPH (P lt; 0.05). Those with BPH had higher BMI, PSA, and Fe and lower Mg, Zn, Cu, Se, and Co compared with the controls (P lt; 0.05). Zn was positively correlated with Mg (r = 0.937, P lt; 0.001, Cu (r = 0.548, P = 0.002), Se (r = 0.731, P lt; 0.001), and Co (r=0.733, P lt; 0.001) only in the men with PCa. Levels of Cu, Mg, and Se were associated with the risk of BPH and PCa.Conclusion: The men with prostate disease were found to have higher levels of lead and iron and lower magnesium, copper, selenium, and zinc, which necessitate assessment of these elements for early detection of prostate cancer and monitoring the progression of the disease.
Keywords :
Metals , Heavy , Prostate , Neoplasms
Journal title :
Middle East Journal of Cancer (MEJC)
Journal title :
Middle East Journal of Cancer (MEJC)
Record number :
2740062
Link To Document :
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