Title of article :
The Investigation of Prophylactic Effect of StrataXRT Gel on Radiation-Induced Dermatitis in Breast Cancer Patients: A Randomized Clinical Trial
Author/Authors :
Omidvari ، Shapour Breast Diseases Research Center - Shiraz University of Medical Sciences , Eskandari ، Zahra Radiation Oncology Department - Shiraz University of Medical Sciences , Nasrollahi ، Hamid Radiation Oncology Department - Shiraz University of Medical Sciences , Ahmadloo ، Niloofar Breast Diseases Research Center - Shiraz University of Medical Sciences , Ansari ، Mansour Breast Diseases Research Center - Shiraz University of Medical Sciences , Hamedi ، Hassan Radiation Oncology Department - Shiraz University of Medical Sciences , Khanjani ، Nezhat Radiation Oncology Department - Shiraz University of Medical Sciences , Kadkhodaei ، Behnam Radiation Oncology Department - Shiraz University of Medical Sciences , Mosalaei ، Ahmad Radiation Oncology Department - Shiraz University of Medical Sciences , Mohammadianpanah ، Mohammad Colorectal Research Center - Shiraz University of Medical Sciences
Abstract :
Background: Breast cancer is among the most prevalent cancers in women. Radiotherapy is an important part in treatment of breast cancer, associated with some side-effects, including skin dermatitis. Dermatitis may be severe and impair quality of life. Multiple agents have been studied, but no standard treatment is yet available. Silicone based gel (StrataXRT) was promising in some studies in reducing skin inflammation and also radiotherapy-induced dermatitis.Method: This was a randomized trial on 100 women with breast cancer who had undergone quadrantectomy for breast cancer. They received StrataXRT gel or best supportive care during radiotherapy. Dermatitis area and grade of dermatitis were measured.Results: Regarding the mean size of radiation-induced dermatitis area, there was a significant difference between the intervention (36.88 cm2 ± 69.93) and control (83.83 cm2 ± 79.34) groups (P = 0.002). During radiotherapy, except in the fourth week, dermatitis was significantly more severe in the control group.Conclusion: It seems that StrataXRT is helpful in decreasing radiotherapy-induced dermatitis.
Keywords :
Breast neoplasms , Radiotherapy , Dermatitis
Journal title :
Middle East Journal of Cancer (MEJC)
Journal title :
Middle East Journal of Cancer (MEJC)
