A Comparative Evaluation of Space Closing Rate between Platelet Rich Plasma Injection and Conventional Method: A Preliminary Study

Aim: Orthodontists and patients prefer minimal time for orthodontic treatment. The submucosal injection ofplatelet-rich plasma (PRP) helps to provide tooth movement without surgery or alveolar bone loss. Thepurpose of this research was to assess the rate of space closure using PRP injection with the conventionalmethod.Methods: In this preliminary study, 10 patients aged 14-20 years, requiring first premolar extractions in botharches using MBT technique were included. This was a split-mouth study wherein, on one side (experimental),space closure was done using a submucosal injection of 0.7 ml PRP, and the other side (control) was subjectedto conventional space closure using an active tie back with a constant force of 200 gm. Statistical analysis wasperformed using a paired t-test. P-value 0.05 was set for statistical significance.Results: The findings of the research showed no significant difference in the rate of space closure between thecase and control groups in the maxilla (P=0.073); however, there was a significant difference between theexperimental and control groupsin the mandible (P=0.04).Conclusion: Analyzing space closure rate between the control and experimental side showed that PRPinjection did affect the acceleration of space closure in the mandible.