Title of article :
The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility
Author/Authors :
Yılmaz ، Seda Güleç Department of Medical Biology - Faculty of Medicine - Yeditepe University , Yencilek ، Faruk Department of Urology - Faculty of Medicine - Yeditepe University , Yıldırım ، Asıf Department of Urology - Göztepe Education and Research Hospital , Akdeniz ، Fatma Tuba Department of Medical Biology - Faculty of Medicine - Yeditepe University , Dalan ، Altay Burak Department of Biochemistry - Faculty of Medicine - Yeditepe University , Barut ، Zerrin Department of Basic Medical Science - Faculty of Dentistry - Antalya Bilim University , İsbir ، Turgay Department of Medical Biology - Faculty of Medicine - Yeditepe University
Abstract :
Purpose: The present study aims to investigate the potential role of Kallikrein 10 (KLK10) genotype and allele frequencies in predisposition to prostate cancer. Materials and Methods: KLK10 (rs7259451) gene polymorphisms were determined by real-time polymerase chain reaction analysis in patients with prostate cancer (n = 69) and controls (n = 76). Results: KLK10 gene frequencies were significantly different in the case and control groups (P = .028). GG carriers were significantly higher in the control group (P = .034), whereas TT carriers were higher in the prostate cancer group (P = .033). Furthermore, The patients with GG genotype had the lowest PSA levels while TT carriers had the highest (P = .005). Conclusion: According to the results, we suggested that carrying variant T allele and also carrying homozygote TT genotype could be a potential risk, while ancestral homozygote GG genotype and G allele are risk reducing factors for prostate cancer.
Keywords :
KLK10 gene , polymorphism , prostate cancer , PSA , rs7259451
Journal title :
Urology Journal
Journal title :
Urology Journal
