Author/Authors :
Beigmohammadi ، Fereshteh Rheumatology Research Center - Tehran University of Medical Sciences , Aslani ، Saeed Rheumatology Research Center - Tehran University of Medical Sciences , Kavosi ، Hoda Rheumatology Research Center, Inflammation Research Center - Tehran University of Medical Sciences , Javinani ، Ali Rheumatology Research Center - Tehran University of Medical Sciences , Mostafaei ، Shayan Department of Neurobiology - Division of Clinical Geriatrics, Care Sciences and Society - Karolinska Institutet , Pournazari ، Mehran Clinical Research Department Center, Imam Raza Hospital - Kermanshah University of Medical Sciences , Tasorian ، Baharak Division of Rheumatology, Department of Internal Medicine - Arak University of Medical Sciences , Farhadi ، Elham Rheumatology Research Center, Inflammation Research Center - Tehran University of Medical Sciences , Hajiabbasi ، Asghar Department of Rheumatology - Guilan Rheumatology Research Center, School of Medicine, Razi Hospital - Guilan University of Medical Sciences , Zayeni ، Habib Department of Rheumatology - Guilan Rheumatology Research Center, School of Medicine, Razi Hospital - Guilan University of Medical Sciences , Khabbazi ، Alireza Connective Tissue Diseases Research Center - Tabriz University of Medical Sciences , Jamshidi ، Ahmadreza Rheumatology Research Center - Tehran University of Medical Sciences , Shenavar Masooleh ، Irandokht Department of Rheumatology - Guilan Rheumatology Research Center, School of Medicine, Razi Hospital - Guilan University of Medical Sciences , Tamartash ، Zahra Rheumatology Research Center - Tehran University of Medical Sciences , Vojdanian ، Mahdi Rheumatology Research Center - Tehran University of Medical Sciences , Mahmoudi ، Mahdi Rheumatology Research Center, Inflammation Research Center - Tehran University of Medical Sciences
Abstract :
Takayasu arteritis (TA) is a chronic inflammatory disorder characterized by vascular damage and fibrosis in the intima that commonly occurs in the aorta. In many damaged sites in TA patients, natural killer (NK) cells have been shown to be hyperactivated and produce inflammatory cytokines and toxic components. Killer cell immunoglobulin-like receptors (KIRs) are found on NK cells and interact with human leukocyte antigen (HLA) class I ligands to activate or suppress NK cells. The present study assessed the possible role of KIR and their HLA ligand genes in susceptibility to TA in Iranian patients. This case-control study included 50 TA patients and 50 healthy subjects. DNA was extracted from whole peripheral blood samples, and polymerase chain reaction with sequence-specific primers (PCR-SSP) was performed to recognize the presence or absence of polymorphism in 17 KIR genes and 5 HLA class I ligands in each participant. Among the KIR and HLA genes, a significant decrease was detected in the frequency of 2DS4 (full allele) in TA patients (38%) compared with healthy controls (82%) (OR=0.13, 95%
Keywords :
Genetic association , Killer cell immunoglobulin , like receptor , Natural killer cell , Takayasu arteritis
