Title of article :
First report of tinea corporis caused by Trichophyton quinckeanum in Iran and its antifungal susceptibility profile
Author/Authors :
Aghili ، Reza Department of Medical Mycology - Invasive Fungi Research Center, Communicable Diseases Institute, School of Medicine - Mazandaran University of Medical Sciences , Alehashemi ، Raheleh Student Research Committee, School of Medicine - Mazandaran University of Medical Sciences , Abastabar ، Mahdi Department of Medical Mycology - Invasive Fungi Research Center, Communicable Diseases Institute, School of Medicine - Mazandaran University of Medical Sciences , Niknejad ، Farhad Dept. of Medical Laboratory Sciences - School of Para Medicine - Golestan University of Medical Sciences , Haghani ، Iman Department of Medical Mycology - Invasive Fungi Research Center, Communicable Diseases Institute, School of Medicine - Mazandaran University of Medical Sciences , Livani ، Fatemeh Department of Internal Medicine, Dermatology Group - School of Medicine - Golestan University of Medical Sciences , Kashiri ، Amineh Department of Internal Medicine, Dermatology Group - School of Medicine - Golestan University of Medical Sciences , Javidnia ، Javad Student Research Committee, School of Medicine - Mazandaran University of Medical Sciences , Nosratabadi ، Mohsen Student Research Committee, School of Medicine - Mazandaran University of Medical Sciences
Abstract :
Background and Purpose: Trichophyton quinckeanum, a known zoophilic dermatophyte responsible for favus form in rodents and camels, is occasionally reported to cause human infections. Case Report: This study aimed to report a case of tinea corporis caused by T. quinckeanum that experienced annular erythematous pruritic plaque with abundant purulent secretions. In June 2021, a 15-year-old girl with an erythematous cup shape lesion on the right wrist bigger than 3 cm in diameter was examined for tinea corporis. Since March, 2016 her family has kept several camels at home. Direct examination of skin scraping and purulent exudates revealed branching septal hyaline hyphae and arthrospore. Morphological evaluation of the recovered isolate from the culture and sequencing of ITS1-5.8S rDNA-ITS2 region resulted in the identification of T. quinckeanum. Antifungal susceptibility testing showed that this isolate had low minimum inhibitory concentration (MIC) values for luliconazole, terbinafine, and tolnaftate, but high MICs to itraconazole, fluconazole, posaconazole, miconazole, isavuconazole, ketoconazole, clotrimazole, and griseofulvin. However, the patient was successfully treated with oral terbinafine and topical ketoconazole. Conclusion: It can be said that T. quinckeanum is often missed or misidentified due to its morphological similarity to T. mentagrophytes/T. interdigitale or other similar species. This dermatophyte species is first reported as the cause of tinea corporis in Iran. As expected, a few months after our study, T. quinckeanum was detected in other areas of Iran, in a few cases.
Keywords :
Antifungal susceptibility profile , T. quinckeanum , Tinea corporis
Journal title :
Current Medical Mycology
Journal title :
Current Medical Mycology
