Author/Authors :
Mehdizadeh ، Behnoush Department of Surgical and Clinical Pathology - Faculty of Medicine - Birjand University of Medical Sciences , Gharib ، Masoumeh Department of Pathology - Faculty of Medicine - Mashhad University of Medical Sciences , Jafarian ، Amir Hossein Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences , Afzalaghaee ، Monavvar Community Medicine Department - Mashhad University of Medical Sciences , Homaee Shandiz ، Fateme Department of RadioOncology - Cancer Research Center, Faculty of Medicine - Mashhad University of Medical Sciences , Irajpour ، Amirhosein Department of Surgery - Shahid Beheshti University of Medical Sciences
Abstract :
Background: Endometrial cancer (EC) is known as the most common malignancy of the female reproductive system, suggested to be associated with hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome (LS). Objectives: Therefore, the aim of the present study was to screen for LS in patients with EC using immunohistochemistry (IHC). Methods: In this retrospective cross-sectional study, the patients with EC, referred to Qaem Hospital, Mashhad, Iran, from 2015 - 2019, were enrolled. Paraffin-embedded tissue blocks were then examined via IHC for the expression of four mismatch repair (MMR) proteins, including MLH1, MSH2, MSH6, andPMS2. The demographic and tumor-related data were also extracted from medical records and pathology reports. The data were consequently analyzed at the significance level of P 0.05. Results: A total number of 100 patients with EC were evaluated using IHC, and 12 (12%) cases were found suspected. As well, no significant relationship was observed between LS and age, tumor site, tumor histology, tumor size, tumor grade, tumor-infiltrating lymphocytes (TILs), and a family/personal history of malignancies. Conclusions: The prevalence of LS based on the IHC expression of the MMR proteins (MLH1, MSH2, MSH6, and PMS2) was 12% in the patients with EC. There was also no significant relationship between the cases suspected and the demographic and tumor-related data.
