Title of article :
The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?
Author/Authors :
Haghi ، Atousa Research Institute for Oncology, Hematology and Cell Therapy, Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center - Tehran University of Medical Sciences , Mohammadi Kian ، Mahnaz Department of Medical Genetics - Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, School of Medicine - Tehran University of Medical Sciences , Salemi ، Mahdieh Research Institute for Oncology, Hematology and Cell Therapy, Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center - Tehran University of Medical Sciences , Eghdami ، Mohammad Reza Department of Social Sciences, Department of Biological Anthropology - Research Institute of Guilan Studies - University of Guilan , Nikbakht ، Mohsen Research Institute for Oncology, Hematology and Cell Therapy, Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center - Tehran University of Medical Sciences
Abstract :
Autophagy plays a critical role in balancing sources of energy in response to harsh conditions and nutrient deprivation. Autophagy allows cells to survive in harsh condition and also serve as a death mechanism. Any dysregulation in autophagy signaling may lead to several disorders. Autophagy has been proposed to explain chemotherapy resistance in acute myeloid leukemia (AML). This signaling pathway can either act as a tumor suppressive function or chemo-resistance mechanism. Conventional chemotherapy drugs enhance apoptosis and indicate clinical benefit, but in some cases, relapse and chemotherapy resistance are observed. In leukemia, autophagy may promote cell survival in response to chemotherapy drugs. Therefore, new strategies by inhibiting or activating autophagy may find a broad application for treating leukemia and may significantly enhance clinical outcomes. In this review, we discussed the dimensional role of autophagy in leukemia.
Keywords :
Autophagy , Acute myeloid leukemia (AML) , Cell survival , Chemoresistanc
Journal title :
International Journal of Hematology-Oncology and Stem Cell Research (IJHOSCR)
Journal title :
International Journal of Hematology-Oncology and Stem Cell Research (IJHOSCR)
