Title of article :
TGF-β Isoforms and Receptors: A Gene Expression Analysis in Multiple Sclerosis Patients and Normal Individuals
Author/Authors :
Shirvani-Farsani ، Zeinab Department of Cell and Molecular Biology - Faculty of Life Sciences and Biotechnology - Shahid Beheshti University , behmanesh ، Mehrdad Department of Genetics - Faculty of Biological Sciences - Tarbiat Modares University , Sahraian ، Mohammad Ali MS Research Center, Neuroscience Institute - Tehran University of Medical Sciences
Abstract :
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), depicted by lymphocytic infiltration and demyelination. MS is associated with the up-regulation of pro-inflammatory and down-regulation of anti-inflammatory cytokines. The purpose of this experimental study was to evaluate the expression level of TGF-β1, TGF-β 2, TGF-β-R1, and TGF-β-R2 mRNAs in peripheral blood mononuclear cells (PBMCs) from MS patients and healthy controls using Real-Time PCR. Our findings indicated that the TGF-β-R1 expression level was 2.25 times higher in controls than in MS patients. Also, a significant correlation between normalized expression of TGF-β-R1 and TGF-β1, or TGF-β2 was observed. Therefore, these genes could likely play an important role in the etiology of MS.
Keywords :
multiple sclerosis , Expression Analysis TGF-β Pathway , TGF- β receptors ,
Journal title :
Personalized Medicine Journal
Journal title :
Personalized Medicine Journal
