CAR T Cell Therapy: A New Weapon to Fight Bladder Cancer

It has been a while since chimeric antigen receptor (CAR)-T cell therapy was introduced as an attractive immunotherapeutic approach to fighting cancer. Despite the remarkable success of this approach in treating blood malignancies such as acute lymphoblastic leukemia (ALL), treatment of solid cancers such as bladder cancer still has many challenges and problems. This work highlights CAR-based cell therapy’s preclinical and clinical studies in bladder cancer, their successes, and the challenges involved in translating this procedure into the clinic.