Title of article :
Potential use of angiotensin receptor blockers in skin pathologies
Author/Authors :
Hedayatyanfard ، Keshvad Department of Physiology - School of Medicine, Cardiovascular Research Center - Alborz University of Medical Sciences , Khalili ، Azadeh Department of Physiology - School of Medicine - Alborz University of Medical Sciences , Karim ، Hosein Department of Cardiology - Cardiovascular Research Center, School of Medicine - Alborz University of Medical Sciences , Nooraei ، Soren Student of School of Veterinary Medicine, Faculty of Veterinary Medicine - University of Shahrekord , Khosravi ، Ehsan Department of Veterinary Surgery - Islamic Azad University, Science and Research Branch , Sadat Haddadi ، Nazgol Department of Dermatology - School of Medicine - University of Massachusetts , Dehpour ، Ahmad Reza Department of Pharmacology - School of Medicine - Tehran University of Medical Sciences , Bayat ، Gholamreza Department of Physiology - School of Medicine - Alborz University of Medical Sciences
Abstract :
Renin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT1R and AT2R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin. Through AT1R, angiotensin II increases proinflammatory cytokines contributing to fibrosis, angiogenesis, proliferation, and migration of immune cells to the skin. In contrast, AT2R suppresses the effects mentioned above. Many studies show that angiotensin receptor blockers (ARBs) and angiotensin-converting enzymes (ACEi) reduce the proinflammatory cytokines and fibrogenic factors including transforming growth factor β (TGF-β), Connective tissue growth factor (CTGF), and IL-6. This review article provides a detailed research study on the implications of ARBs in wound healing, hypertrophic scar, and keloids. We further discuss the therapeutic potentials of ARBs in autoimmune and autoinflammatory skin diseases and cancer, given their anti-fibrotic and anti-inflammatory effects.
Keywords :
Angiotensin II , Cancer , Keloid , scar , Skin disease , Wound healing
Journal title :
Iranian Journal of Basic Medical Sciences
Journal title :
Iranian Journal of Basic Medical Sciences
