Acute Myeloblastic Leukemia with Multiple Extramedullary Relapses

Letter to Editor: Extramedullary relapse is a rare event in acute myeloblastic leukemia (AML) in contrast to acute lymphoblastic leukemia (ALL) which is associated with bone marrow relapses and extramedullary relapses (EMR) due to sanctuary sites such as testis and central nerve system (CNS).1 Only 2% of patients with AML with medullary relapse were detected to have coexistent testicular relapse, although this ratio is much higher as 30-70 % in autopsy series.1, 2 Testicular relapse harbours systemic relapse and aggressive systemic and adjunctive local treatments such as radiotherapy (RT) need to be started appropriately; although there is not any worldwide determined algorithm for isolated EMR, yet.