Title of article
Acute Lymphoblastic Leukemia Switch Lineage upon Relapse to Acute Bilineage Leukemia: A Case Report
Author/Authors
mehrzad, valiollah isfahan university of medical sciences - internal medicine department, hematology division, Isfahan, Iran , nematollahi, pardis isfahan university of medical science - omid professional hospital - pathology department, Isfahan, Iran , emami, anahita isfahan university of medical sciences - internal medicine department, hematology division, Isfahan, Iran , hosseini, forough isfahan university of medical sciences - internal medicine department, hematology division, Isfahan, Iran
From page
22
To page
25
Abstract
Although acute leukemia commonly relapses in adults, the conversion of leukemic cell lineage (lymphoid or myeloid) upon relapse has rarely taken place. “Lineage switch” is a term widely used to define the leukemic lineage transformation as assessed by morphology, cytochemistry, and immunophenotyping from diagnosis to relapse. In most lineage switch cases, B-cell lymphoblastic leukemia/ lymphoma relapses as acute myeloid leukemia or vice versa. Here, we report an exceedingly rare case of T-cell acute lymphoblastic leukemia relapsing as mixed phenotype acute leukemia.
Keywords
Acute lymphoblastic leukemia (ALL) , Lineage switch , Mixed , phenotype acute leukemias , (MPALs) , Acute bilineage leukemia
Journal title
Iranian Journal of Blood and Cancer (IJBC)
Journal title
Iranian Journal of Blood and Cancer (IJBC)
Record number
2747799
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