Author/Authors :
oladipo, e. kolawole ladoke akintola university of technology - department of pure and applied biology (microbiology unit), Ogbomoso, Nigeria , oladipo, e. kolawole adeleke university - department of microbiology, virus research laboratory, Ede, Nigeria , oloke, j. kola ladoke akintola university of technology - department of pure and applied biology (microbiology unit), Ogbomoso, Nigeria , adeniji, j. adekunle university of ibadan - college of medicine - virology department, Ibadan, Nigeria
Abstract :
Understanding the pathogenicity of avian influenza viruses in poultry is an important scientific and public health challenge because of antigenic shift/drift and a source of novel, potentially human- pathogenic strains. We have previously isolated an influenza A strain (H5N1/2014/Ogbomoso) from an outbreak among pig and have now aimed to assess its pathogenicity in an avian host and to categorize it as a low or high pathogenic strain. Intravenous pathogenicity index of the isolated virus was assayed using experimental infection of 6 weeks old pathogen-specific free chicken. The peak of clinical signs was on day three post-infection, and one death was observed on day eight. The intravenous pathogenicity index of this isolate was 0.08. This results classify this isolate as a low pathogenic avian influenza strain.
Keywords :
H5N1 , Influenza , Intravenous pathogenicity , Nigeria , Ogbomoso.
