Author/Authors :
Wiweko ، Budi Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, - Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia Reproductive Medicine Research and Training Center , Yasmin IVF Clinic - Universitas Indonesia , Surya ، Ervan Department of Obstetrics and Gynecology - Faculty of Medicine - University of Indonesia , Silvana ، Vita Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, - Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia Reproductive Medicine Research and Training Center , Yasmin IVF Clinic - Universitas Indonesia , Maidarti ، Mila Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, - Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia Reproductive Medicine Research and Training Center , Yasmin IVF Clinic - Universitas Indonesia , Kemal Harzif ، Achmad Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology - Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia Reproductive Medicine Research and Training Center , Yasmin IVF Clinic - Universitas Indonesia , Pratama ، Gita Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology - Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia Reproductive Medicine Research and Training Center , Yasmin IVF Clinic - Universitas Indonesia , Sumapraja ، Kanadi Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology - Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia Reproductive Medicine Research and Training Center , Yasmin IVF Clinic - Universitas Indonesia , Muharam ، R Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology - Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia Reproductive Medicine Research and Training Center , Yasmin IVF Clinic - Universitas Indonesia , Hestiantoro ، Andon Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology - Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia Reproductive Medicine Research and Training Center , Yasmin IVF Clinic - Universitas Indonesia
Abstract :
Background: In vitro fertilization (IVF) remains a main treatment for infertility cases. Post-injection human chorionic gonadotropin (hCG) level is an essential factor in determining oocyte maturation rate in IVF. This study aimed to determine the relationship between 12 hours post-injection serum hCG level and oocyte maturation rate among IVF participants. Materials and Methods: A cross-sectional study on IVF participants was done at a tertiary hospital in Indonesia from January 2020 to December 2021. Subjects were injected with 250 μg of recombinant-hCG (r-hCG) subcutaneously. Twelve hours post-injection serum hCG levels and oocyte maturation rate data were retrieved and analyzed accordingly. Results: Twenty-eight subjects were recruited into the study. Higher 12 hours post-injection serum hCG was related to oocyte maturation rate (P=0.046). The cut-off point of 12 hours post-injection serum hCG to predict better oocyte maturation rate was 90.15 mIU/mL (sensitivity 68.2%, specificity 83.3%). Oocyte maturation rate may be predicted using body mass index (BMI) and 12 hours post-injection serum hCG. Conclusion: Higher 12 hours post-injection serum hCG was associated with a higher oocyte maturation rate in IVF subjects.
Keywords :
Human Chorionic Gonadotropin Hormone , In Vitro Fertilization , Oocyte , Oocyte Maturation
