Title of article
Dietary linoleic acid intake in relation to breast cancer: A case-control study
Author/Authors
Joya ، Muhammad Reza Department of Community Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences , Naghshi ، Sina Student Research Committee - Tabriz University of Medical Sciences , Sadeghi ، Omid Department of Community Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences , Benisi-Kohansal ، Sanaz Department of Community Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences , Azadbakht ، Leila Department of Community Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences , Lotfi ، Keyhan Department of Community Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences , Ostadrahimi ، Alireza Department of Clinical Nutrition - Nutrition Research Center, School of Nutrition and Food Science - Tabriz University of Medical Sciences , Tutunchi ، Helda Endocrine Research Center - Tabriz University of Medical Sciences , Esmaillzadeh ، Ahmad Department of Community Nutrition - School of Nutritional Sciences and Dietetics, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute - Tehran University of Medical Sciences
From page
219
To page
226
Abstract
Background: The present study aimed to investigate the association between dietary linoleic acid (LA) intake and breast cancer in women. Methods: In this population-based case-control study, we enrolled 350 pathologically confirmed breast cancer cases and 700 controls which were matched with cases in terms of age and socioeconomic status. Dietary intakes were assessed using a 106-item Willett-format semi-quantitative dish-based food frequency questionnaire (DS-FFQ). Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated. Results: A significant inverse association was found between LA intake and odds of breast cancer (OR: 0.41, 95% CI: 0.30-0.56). After adjusting for potential confounders, women in the highest tertile of dietary LA intake were 48% less likely to have breast cancer compared with those in the lowest tertile (OR: 0.52, 95% CI: 0.28-0.95). Such a significant inverse association was also seen among normal-weight women (OR: 0.29, 95% CI: 0.14-0.63), and premenopausal women (OR: 0.15, 95% CI: 0.02-0.95). Conclusion: The findings of current study provide evidence for a protective role of LA against breast cancer particularly among normal-weight and premenopausal women. Prospective studies are needed to confirm this association.
Keywords
Breast neoplasms , Linoleic acid , Diet , Case , control studies , Fatty acids
Journal title
Health Promotion Perspectives (HPP)
Journal title
Health Promotion Perspectives (HPP)
Record number
2751598
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