Author/Authors :
Sanaie ، Sarvin Research Center for Integrative Medicine in Aging, Aging Research Institute - Tabriz University of Medical Sciences , Dolati ، Sanam Physical Medicine and Rehabilitation Research Center, Aging Research Institute - Tabriz University of Medical Sciences , Montazer ، Majid Department of Cardiothoracic Surgeries - School of Medicine - Tabriz University of Medical Sciences , Ranjbari ، Sarina Student Research Committee - Tabriz University of Medical Sciences , Fathalizadeh ، Arezoo Student Research Committee - Tabriz University of Medical Sciences , Shadvar ، Kamran Department of Anesthesiology and Critical Care Medicine - School of Medicine - Tabriz University of Medical Sciences , Faramarzi ، Elnaz Liver and Gastrointestinal Diseases Research Center - Tabriz University of Medical Sciences , Mahmoodpoor ، Ata Research Center for Integrative Medicine in Aging, Aging Research Institute - Tabriz University of Medical Sciences
Abstract :
Background: Plasma total cholesterol is considered a negative acute phase reactant. In various pathological conditions, such as trauma, sepsis, burns, and liver dysfunction, as well as post-surgery, serum cholesterol level decreases. This study aimed to investigate the role of lipid profiles in determining the probability of organ dysfunction after surgery.Methods: This cross-sectional study included patients who underwent thoracoabdominal surgery and were admitted to the intensive care unit of Imam Reza Hospital in Tabriz, Iran, between October 2016 and September 2018. During the first two days of admission, blood samples were taken, and serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and albumin were measured. The relation between the changes in these laboratory markers and six organ functions including cardiovascular, respiratory, renal, central nervous system, hepatic, and hematologic, length of stay in the hospital and intensive care unit, mechanical ventilation duration, and vasopressor use were investigated. The independent t test was used to compare continuous variables. The association between different variables and organ dysfunction and mortality was evaluated by using logistic regression.Results: The serum TC increased the risk of mortality (OR=1.09, 95%CI=1.06-1.11, P lt;0.001), renal dysfunction (OR=1.09, 95%CI=1.06-1.12; P lt;0.001), liver dysfunction (OR=1.07, 95%CI=1.03-1.10; P lt;0.001), respiratory dysfunction (OR=1.08, 95%CI=1.05-1.13; P lt;0.001). Moreover, LDL, HDL, and TG were found to be inversely related to mortality, organ dysfunction, length of stay in the hospital and intensive care unit, mechanical ventilation duration, and vasopressor use. Conclusion: TC could be considered a risk factor for mortality, organ dysfunction, and clinical outcomes. On the other hand, LDL, HDL, and TG played a protective role in the patients’ mortality, organ dysfunction, and clinical outcomes.
