Kemik İliği Stroması: Hücreleri ve Mikroçevresi

Bone marrow is a specialized site of structural stromal cells of immature and mature blood cells. It is found in bones such as the human skull, rib cage, ribs, pelvis and femur. Bone marrow is connected to the invention and circulation through specialized blood vessels, including specialized fenestrated capillaries called sinusoids. These sinusoids penetrate sponge-like extracellular cells which is produced by fibroblasts, and place hematopoietic cells, proteins in separate compartments. Bone marrow contains specialized microchips containing hematopoietic cells, stromal cells, ECM, cytokines, growth factors and chemokines. In this microenvironment, developing hematopoietic cells are signaling for survival, differentiation and proliferation. Bone marrow microenvironment plays an important role in the development and progression of leukemia and other types of cancer. In many ways, bone marrow provides an ideal microenvironment for growth of malignant cells. In this review, general information about the role of the bone marrow microenvironment and the cells forming the microenvironment is given.