Author/Authors :
Darabi ، Zahra Department of Nutrition - School of Public Health, Research Center for Food Hygiene and Safety - Shahid Sadoughi University of Medical Sciences , Jambarsang ، Sara Department of Biostatistics and Epidemiology - Center for Healthcare Data Modeling, School of Public Health - Shahid Sadoughi University of Medical Sciences , Vahidi Mehrjardi ، Mohammad Yahya Department of Genetic - Shahid Sadoughi University of Medical Sciences , Seyed Hosseini ، Mostafa Yazd Cardiovascular Research Center, Non-Communicable Diseases Research Institute - Shahid Sadoughi University of Medical Sciences , Sarebanhassanabadi ، Mohammadtaghi Yazd Cardiovascular Research Center, Non-Communicable Diseases Research Institute - Shahid Sadoughi University of Medical Sciences , Hosseinzadeh ، Mahdieh Department of Nutrition - School of Public Health, Research Center for Food Hygiene and Safety - Shahid Sadoughi University of Medical Sciences , Beigrezaei ، Sara Department of Nutrition - School of Public Health, Research Center for Food Hygiene and Safety - Shahid Sadoughi University of Medical Sciences , Ahmadi Vasmehjani ، Azam Department of Nutrition - School of Public Health, Research Center for Food Hygiene and Safety - Shahid Sadoughi University of Medical Sciences , Taftian ، Marzieh Department of Nutrition - School of Public Health, Research Center for Food Hygiene and Safety - Shahid Sadoughi University of Medical Sciences , Arabi ، Vahid Department of Nutrition - School of Public Health, Research Center for Food Hygiene and Safety - Shahid Sadoughi University of Medical Sciences , Motallaei ، Maryam Department of Nutrition - School of Public Health, Research Center for Food Hygiene and Safety - Shahid Sadoughi University of Medical Sciences , Golvardi Yazdi ، Faezeh Department of Nursing - School of Nursing and Midwifery - Shahid Sadoughi University of Medical Sciences and Health Services , Salehi-Abargouei ، Amin Department of Nutrition - School of Public Health, Research Center for Food Hygiene and Safety - Shahid Sadoughi University of Medical Sciences , Nadjarzadeh ، Azadeh Department of Nutrition - School of Public Health, Research Center for Food Hygiene and Safety - Shahid Sadoughi University of Medical Sciences
Abstract :
Introduction: Genetic and environmental factors are involved in the pathogenesis of cardiovascular diseases (CVDs). The aim of the study was to investigate between the genotype of the NFKB1 gene and the cardiometabolic risk factor in patients undergoing coronary angiography. Methods: This cross-sectional study was conducted on 462 adults (male and women) aged between 35 and 75 years who referred to Afshar Hospital for coronary angiography in 2021- 2022. The polymerase chain reaction restriction fragment length polymorphism method was used to detect the genotype of rs28362491. Biochemical parameters were measured using commercial kits. Gensini and Syntax scores were calculated using the angiography result to assess the extent of coronary artery stenosis. We used multivariate logistic regression analysis to examine the relationship between genotype variants and cardiometabolic risk factors. Results: There was no association between variant genotypes and abnormally levels of serum alanine aminotransferase (ALT) (P value=0.51), aspartate aminotransferase (AST) (P value=0.99), triglyceride (TG) (P value=0.48), total cholesterol (P value=0.79), low density lipoprotein-cholestero (LDL-C) (P value=0.31), high-density lipoprotein-cholesterol (HDL-C) (P value=0.53), fast blood sugar (FBS) (P value=0.39), systolic blood pressure (P value=0.14), diastolic blood pressure (P value=0.64), Gensini score (P value=0.48) and syntax score (P value=0.74) in the crude model even after adjustment for confounding factors. Conclusion: We found no association between the ATTG polymorphism and cardiometabolic risk factors in patients who had coronary angiography. Further investigations are needed to assess the association between variants of 28362491 and cardiometabolic markers.
Keywords :
NFKB1 polymorphism , Cardiovascular disease , Lipid profile , Liver enzymes
