Author/Authors :
Shaseb ، Elnaz Department of Pharmacotherapy - Drug Applied Research Center, Faculty of Pharmacy - Tabriz University of Medical Sciences , Ghaffary ، Saba Faculty of Pharmacy, Hematology and Oncology Research Center - Tabriz University of Medical Sciences , Garjani ، Alireza Faculty of Pharmacy - Tabriz University of Medical Sciences , Zoghi ، Elnaz Faculty of Pharmacy - Tehran University of Medical Sciences , Maleki Dizaji ، Nasrin Faculty of Pharmacy - Tabriz University of Medical Sciences , Soltani ، Somaieh Faculty of Pharmacy - Tabriz University of Medical Sciences , Sarbakhsh ، Parvin Road Traffic Injury Research Center - Tabriz University of Medical Sciences , Somi ، Mohammad Hossein Liver and Gastrointestinal Disease Research Center - Tabriz University of Medical Sciences , Valizadeh ، Parya School of Medicine - Tehran University of Medical Sciences , Taghizadieh ، Ali Tuberculosis and Lung Diseases Research Center - Tabriz University of Medical Sciences , Faghihdinevari ، Masood Liver and Gastrointestinal Disease Research Center - Tabriz University of Medical Sciences , Varshochi ، Mojtaba Infectious and Tropical Diseases Research Center - Tabriz University of Medical Sciences , Naghily ، Behrooz Infectious and Tropical Diseases Research Center - Tabriz University of Medical Sciences , Bayatmakoo ، Zhinous Infectious and Tropical Diseases Research Center - Tabriz University of Medical Sciences , Saleh ، Parviz Infectious and Tropical Diseases Research Center - Tabriz University of Medical Sciences , Taghizadeh ، Sepehr Infectious and Tropical Diseases Research Center - Tabriz University of Medical Sciences , Haghdoost ، Mehdi Infectious and Tropical Diseases Research Center - Tabriz University of Medical Sciences , Owaysi ، Hamid Infectious and Tropical Diseases Research Center - Tabriz University of Medical Sciences , Ravanbakhsh Ghavghani ، Fatemeh Infectious and Tropical Diseases Research Center - Tabriz University of Medical Sciences , Tarzamni ، Mohammad Kazem Department of Radiology, Medical Radiation Sciences Research Group - Imam Reza Hospital - Tabriz University of Medical Sciences , Moradi ، Rojin Department of Radiology, Medical Radiation Sciences Research Group - Imam Reza Hospital - Tabriz University of Medical Sciences , Javan Ali Azar ، Fateme Faculty of Medicine - Tabriz University of Medical Sciences , Shabestari Khiabani ، Saeid Department of Pharmacotherapy - Drug Applied Research Center - Tabriz University of Medical Sciences , Ghazanchaei ، Ardavan Imam Reza Hospital - Tabriz University of Medical Sciences , Hamedani ، Sana Faculty of Pharmacy - Tabriz University of Medical Sciences , Hatefi ، Shahabeddin Faculty of Pharmacy - Tabriz University of Medical Sciences
Abstract :
Purpose: The aim of the study is to evaluate the effect of metformin in complication improvement of hospitalized patients with COVID-19. Methods: This was a randomized clinical trial that involved 189 patients with confirmed COVID-19 infection. Patients in the intervention group received metformin-500 mg twice daily. Patients who received metformin before admission were excluded from the control group. Patients who were discharged before taking at least 2000 mg of metformin were excluded from the study. Primary outcomes were vital signs, need for ICU admission, need for intubation, and mortality. Results: Data showed that patients with diabetes with previous metformin in their regimen had lower percentages of ICU admission and death in comparison with patients without diabetes (11.3% vs. 26.1% (P=0.014) and 4.9% vs. 23.9% (P≤0.001), respectively). Admission time characteristics were the same for both groups except for diabetes and hyperlipidemia, which were significantly different between the two groups. Observations of naproxen consumption on endpoints, duration of hospitalization, and the levels of spO2 did not show any significant differences between the intervention and the control group. The adjusted OR for intubation in the intervention group versus the control group was 0.21 [95% CI, 0.04-0.99 (P=0.047)]. Conclusion: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates.
Keywords :
COVID , 19 , Diabetes mellitus , Metformin , Intubation
