The Effect of Combined Exercises and Consumption of Mulberry Leaf Extract on Serum Inflammatory Markers Level in Elderly Type 2 Diabetes Mellitus Men

Objective: This study aimed to investigate the effect of 8 weeks combined exercise and consumption of Mulberry leaf extract on the serum levels of inflammatory and atherosclerosis indicators in elderly men with type 2 diabetes mellitus (T2DM). Materials and Methods: 40 elderly men T2DM aged between 65 to 70 years old were purposefully selected and randomly divided into five equal groups (training, supplement, training+ supplement, placebo, and control). A daily dose of 1000 mg Mulberry leaf extract, 3 times a day, was used for 2 months by the supplement group. Training groups performed combined exercises for eight weeks, each week three sessions of 90 minutes. Results: The results showed that the amount of salusin-β and interleukin-6 in the training, training + supplement and supplement groups decreased significantly at the end of the study; Meanwhile, the level of salusin-α increased significantly in the training (P= 0.001), training + supplement (P= 0.001) and supplement (P= 0.01) groups. Also, the results of the covariance analysis showed that the amount of salusin-β and interleukin 6 were lower (P= 0.001), and the level of salusin-α was higher significantly in the training (P= 0.001), training +supplement (P= 0.001), and supplement (P= 0.001) groups compared to the control groups. Conclusion: It seems that the consumption of Mulberry leaf extract, and combined exercises, is effective in controlling the inflammatory indicators and atherosclerosis related to diabetes in the T2DM elderly.