Title of article :
Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance
Author/Authors :
Dabbaghipour ، Reza Department of Medical Genetics - Shiraz University of Medical Sciences , Ahmadi ، Elham Immunology Research Center - Tabriz University of Medical Sciences , Entezam ، Mona Department of Medical Genetics - Shiraz University of Medical Sciences , Rahbar Farzam ، Omid Immunology Research Center - Tabriz University of Medical Sciences , Baghbanzadeh ، Amir Immunology Research Center - Tabriz University of Medical Sciences , Saber Sichani ، Ali Department of Biology - College Station - Texas A M University , Jalilzadeh ، Nazila Immunology Research Center - Tabriz University of Medical Sciences , Jafarlou ، Mahdi Immunology Research Center - Tabriz University of Medical Sciences , Baradaran ، Behzad Department of Immunology - Immunology Research Center, Faculty of Medicine - Tabriz University of Medical Sciences
Abstract :
Scientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in the Th17/Treg ratio. In this review study, we overviewed the association between LncRNAs and Th17/Treg, with the potential of providing novel prognostic and diagnostic biomarkers and promising therapeutic targets in various diseases, particularly cancer.
Keywords :
Long non , coding RNA , Regulatory T cells , T helper 17 cells
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
