Title of article :
A Study of Sonodynamic Therapy of Melanoma C540 Cells in Vitro by Titania/Gold Nanoparticles
Author/Authors :
Perota ، Ghazale Department of Medical Physics and Engineering - School of Medicine, Nanomedicine and Nanobiology Research Center - Shiraz University of Medical Sciences , Faghani-Eskandarkolaei ، Parsa Department of Medical Physics and Engineering - School of Medicine - Shiraz University of Medical Sciences , Zahraie ، Niloofar Department of Medical Physics and Engineering - School of Medicine, Nanomedicine and Nanobiology Research Center - Shiraz University of Medical Sciences , Zare ، Mohammad Hosein Department of Medical Physics - School of Medicine - Shahid Sadoughi University of Medical Science , Sattarahmady ، Naghmeh Department of Medical Physics and Engineering - School of Medicine, School of Medicine, Nanomedicine and Nanobiology Research Center - Shiraz University of Medical Sciences
Abstract :
Background: Sonodynamic Therapy (SDT), a safe and non-invasive strategy in tumor therapy, is in development using novel sono-sensitizers, activated by low-intensity ultrasound radiation. SDT mainly progresses through Reactive Oxygen Species (ROS) generation followed by cell annihilation. Objective: The current study aimed to investigate the effect of ultrasound therapy with titania/gold nanoparticles (NPs) on melanoma cancer. Material and Methods: In this experimental study, Titania/gold NPs (TGNPs) were synthesized, and their activity was investigated in sonodynamic therapy of a melanoma cancer cell line (C540). SDT was performed at 1.0 W cm^-2 and 1.0 MHz for one minute. Results: The synthesized NPs that comprised gold NPs of 10 nm into titania NPs of 20 nm showed great stability and cytocompatibility. While TGNPs were biocompatible, a remarkable rate of cell ablation was observed upon ultrasound irradiation due to ROS generation. Conclusion: The SDT using TGNPs can be introduced as an alternative and low-cost treatment method for melanoma malignancy.
Keywords :
Malignant Melanoma , Metal Nanoparticles , Gold , Non , Ionizing Radiation , Reactive Oxygen Species
Journal title :
Journal of Biomedical Physics and Engineering
Journal title :
Journal of Biomedical Physics and Engineering
