Title of article
Targeted Solid Lipid Nanoparticles Formulation for Colon Cancer Treatment and Cytotoxicity Assessment Using HT29 Cell Line
Author/Authors
Moghimipour ، Eskandar Nanotechnology Research Center - Ahvaz Jundishapur University of Medical Sciences , Abedini ، Maryam Toxicology Research Center - Ahvaz Jundishapur University of Medical Sciences , Handali ، Somayeh Medical Biomaterials Research Center - Tehran University of Medical Sciences
From page
1
To page
9
Abstract
Background: Several pharmacological effects have been attributed to thymol. However, limitations such as low solubility in water, low bioavailability, and high volatility have limited its use. Objectives: The present study aimed to prepare and characterize thymol-loaded solid lipid nanoparticles (SLNs) to improve the efficacy of thymol. Methods: Thymol-loaded SLNs were characterized by atomic force microscopy (AFM), differential scanning calorimetry (DSC), and Fourier transformed infrared spectroscopy (FT-IR). Cytotoxicity study and hemolysis assay were also performed. Results: The in vitro drug release showed a sustained manner. Also, SLNs loaded with thymol showed higher cytotoxicity than free thymol, and the hemolysis results indicated the blood biocompatibility of SLNs. Conclusions: As nanocarriers, SLNs can open a new avenue for improving the efficacy of thymol in cancer treatment.
Keywords
Thymol , Solid Lipid Nanoparticles , Cancer , Drug Delivery System
Journal title
Jundishapur Journal of Natural Pharmaceutical Products (JJNPP)
Journal title
Jundishapur Journal of Natural Pharmaceutical Products (JJNPP)
Record number
2758841
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